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Loss of Fbw7 Reprograms Adult Pancreatic Ductal Cells into α, δ, and β Cells

The adult pancreas is capable of limited regeneration after injury but has no defined stem cell population. The cell types and molecular signals that govern the production of new pancreatic tissue are not well understood. Here, we show that inactivation of the SCF-type E3 ubiquitin ligase substrate...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Sancho, Rocio, Gruber, Ralph, Gu, Guoqiang, Behrens, Axel
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cell Press 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136739/
https://ncbi.nlm.nih.gov/pubmed/25105579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2014.06.019
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