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Effect of Genetic Variants, Especially CYP2C9 and VKORC1, on the Pharmacology of Warfarin
The genes encoding the cytochrome P450 2C9 enzyme (CYP2C9) and vitamin K-epoxide reductase complex unit 1 (VKORC1) are major determinants of anticoagulant response to warfarin. Together with patient demographics and clinical information, they account for approximately one-half of the warfarin dose v...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4134937/ https://ncbi.nlm.nih.gov/pubmed/23041981 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1055/s-0032-1328891 |
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