Multifactorial T cell Hypofunction that is Reversible Can Limit the Efficacy of Chimeric Antibody Receptor-transduced Human T cells in Solid Tumors

PURPOSE: Immunotherapy using vaccines or adoptively transferred tumor infiltrating lymphocytes (TILs) is limited by T cell functional inactivation within the solid tumor microenvironment. The purpose of this study was to determine if a similar tumor-induced inhibition occurred with genetically-modif...

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Main Authors: Moon, Edmund K., Wang, Liang-Chuan, Dolfi, Douglas V., Wilson, Caleph B., Ranganathan, Raghuveer, Sun, Jing, Kapoor, Veena, Scholler, John, Puré, Ellen, Milone, Michael C., June, Carl H., Riley, James L., Wherry, E. John, Albelda, Steven M.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4134701/
https://ncbi.nlm.nih.gov/pubmed/24919573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-2627
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