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Tetrasubstituted pyrazinones derived from the reaction of praziquantel with N-bromosuccinimide

When praziquantel was exposed to N-bromosuccinimide in the presence of ethanol, a tricyclic 3-bromo-1-ethoxy pyrazinone was formed. From this and the analogous 1,3-dibromopyrazinone, a small library of 3-alkylamino-1-ethoxy, 1,3-dialkoxy, 3-alkoxy-1-bromo, and 3-alkylamino-1-bromo substituted pyrazi...

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Detalhes bibliográficos
Main Authors: Zhao, Qingjie, Wang, Chunkai, Ezell, Edward L., Dong, Yuxiang, Vennerstrom, Jonathan L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128413/
https://ncbi.nlm.nih.gov/pubmed/25125709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2014.06.083
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