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Molecular Basis of Substrate Recognition and Degradation by Human Presequence Protease
Human Presequence Protease (hPreP) is an M16 metalloprotease localized in mitochondria. There, hPreP facilitates proteostasis by utilizing a ∼13,300Å(3) catalytic chamber to degrade a diverse array of potentially toxic peptides, including mitochondrial presequences and amyloid-β (Aβ), the latter of...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4128088/ https://ncbi.nlm.nih.gov/pubmed/24931469 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2014.05.003 |
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