Molecular Basis of Substrate Recognition and Degradation by Human Presequence Protease

Human Presequence Protease (hPreP) is an M16 metalloprotease localized in mitochondria. There, hPreP facilitates proteostasis by utilizing a ∼13,300Å(3) catalytic chamber to degrade a diverse array of potentially toxic peptides, including mitochondrial presequences and amyloid-β (Aβ), the latter of...

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Hlavní autoři: King, John V., Liang, Wenguang G., Scherpelz, Kathryn P., Schilling, Alexander B., Meredith, Stephen C., Tang, Wei-Jen
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128088/
https://ncbi.nlm.nih.gov/pubmed/24931469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2014.05.003
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