(99m)Tc-Labeled HYNIC-DAPI Causes Plasmid DNA Damage with High Efficiency

(99m)Tc is the standard radionuclide used for nuclear medicine imaging. In addition to gamma irradiation, (99m)Tc emits low-energy Auger and conversion electrons that deposit their energy within nanometers of the decay site. To study the potential for DNA damage, direct DNA binding is required. Plas...

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Main Authors: Kotzerke, Joerg, Punzet, Robert, Runge, Roswitha, Ferl, Sandra, Oehme, Liane, Wunderlich, Gerd, Freudenberg, Robert
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4123991/
https://ncbi.nlm.nih.gov/pubmed/25098953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0104653
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