15-Deoxy-γ12,14-prostaglandin J2 Reduces Liver Impairment in a Model of ConA-Induced Acute Hepatic Inflammation by Activation of PPARγ and Reduction in NF-κB Activity

Objective. 15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) reduces inflammation and has been identified as an anti-inflammatory prostaglandin in numerous animal models. In this study, we investigated both effects of 15d-PGJ2 and its protection mechanism in concanavalin A- (ConA-) induced autoimmune hepa...

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Hauptverfasser: Chen, Kan, Li, Jingjing, Wang, Junshan, Xia, Yujing, Dai, Weiqi, Wang, Fan, Shen, Miao, Cheng, Ping, Zhang, Yan, Wang, Chengfen, Yang, Jing, Zhu, Rong, Zhang, Huawei, Zheng, Yuanyuan, Lu, Jie, Fan, Zhuoyi, Zhou, Yingqun, Guo, Chuanyong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi Publishing Corporation 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121249/
https://ncbi.nlm.nih.gov/pubmed/25120564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/215631
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