A virtual screen identified C96 as a novel inhibitor of phosphatidylinositol 3-kinase that displays potent preclinical activity against multiple myeloma in vitro and in vivo

The phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway is emerging as a promising therapeutic target for multiple myeloma (MM). In the present study, we performed a virtual screen against 800,000 of small molecule compounds by targeting PI3Kγ. C96, one of such compounds, inhibited PI3K activ...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Tang, Juan, Zhu, Jingyu, Yu, Yang, Zhang, Zubin, Chen, Guodong, Zhou, Xiumin, Qiao, Chunhua, Hou, Tingjun, Mao, Xinliang
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Impact Journals LLC 2014
Gaiak:
Research Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4116524/
https://ncbi.nlm.nih.gov/pubmed/25003534
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak