A virtual screen identified C96 as a novel inhibitor of phosphatidylinositol 3-kinase that displays potent preclinical activity against multiple myeloma in vitro and in vivo

The phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway is emerging as a promising therapeutic target for multiple myeloma (MM). In the present study, we performed a virtual screen against 800,000 of small molecule compounds by targeting PI3Kγ. C96, one of such compounds, inhibited PI3K activ...

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Bibliographische Detailangaben
Hauptverfasser: Tang, Juan, Zhu, Jingyu, Yu, Yang, Zhang, Zubin, Chen, Guodong, Zhou, Xiumin, Qiao, Chunhua, Hou, Tingjun, Mao, Xinliang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2014
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4116524/
https://ncbi.nlm.nih.gov/pubmed/25003534
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