IRF-1 regulates alternative mRNA splicing of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in breast epithelial cells generating an immunoreceptor tyrosine-based inhibition motif (ITIM) containing isoform

BACKGROUND: Interferon regulatory factor-1 (IRF-1) is a master regulator of IFN-γ induced gene transcription. Previously we have shown that IRF-1 transcriptionally induces CEACAM1 via an ISRE (Interferon-Stimulated Response Element) in its promoter. CEACAM1 pre-mRNA undergoes extensive alternative s...

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Autori principali: Dery, Kenneth J, Kujawski, Maciej, Grunert, David, Wu, Xiwei, Ngyuen, Tung, Cheung, Celeste, Yim, John H, Shively, John E
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2014
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4113144/
https://ncbi.nlm.nih.gov/pubmed/24650050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-64
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