Downregulation of Sirt1 as aging change in advanced heart failure

BACKGROUND: In congestive heart failure the balance between cell death and cell survival in cardiomyocytes is compromised. Sirtuin 1 (Sirt1) activates cell survival machinery and has been shown to be protective against ischemia/reperfusion injury in murine heart. The role of Sirt1 in heart failure,...

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Autori principali: Lu, Tse-Min, Tsai, Jia-Yun, Chen, Yen-Chung, Huang, Chun-Yang, Hsu, Hung-Lung, Weng, Chi-Feng, Shih, Chun-Che, Hsu, Chiao-Po
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2014
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4113120/
https://ncbi.nlm.nih.gov/pubmed/24913149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1423-0127-21-57
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