Enhanced oral absorption and therapeutic effect of acetylpuerarin based on D-α-tocopheryl polyethylene glycol 1000 succinate nanoemulsions

BACKGROUND: Acetylpuerarin (AP), because of its lower water solubility, shows poor absorption that hinders its therapeutic application. Thus, the aim of this study was to prepare nanoemulsions for AP, enhance its oral bioavailability, and thus improve the therapeutic effect. METHODS: The nanoemulsio...

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Главные авторы: Sun, Deqing, Wei, Xinbing, Xue, Xia, Fang, Zengjun, Ren, Manru, Lou, Haiyan, Zhang, Xiumei
Формат: Artigo
Язык:Inglês
Опубликовано: Dove Medical Press 2014
Предметы:
Original Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4111663/
https://ncbi.nlm.nih.gov/pubmed/25071371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S63777
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