RIPK4 phosphorylates Dishevelled proteins to regulate canonical Wnt signaling

Receptor interacting protein kinase 4 (RIPK4) is required for epidermal differentiation (1–4) and is mutated in Bartsocas-Papas syndrome (5, 6). While RIPK4 binds protein kinase C (5, 6), RIPK4 signaling mechanisms are largely unknown. We show that ectopic RIPK4 induces cytosolic β-catenin accumulat...

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Hauptverfasser: Huang, XiaoDong, McGann, James C., Liu, Bob Y., Hannoush, Rami N., Lill, Jennie R., Pham, Victoria, Newton, Kim, Kakunda, Michael, Liu, Jinfeng, Yu, Christine, Hymowitz, Sarah G., Hongo, Jo-Anne, Wynshaw-Boris, Anthony, Polakis, Paul, Harland, Richard M., Dixit, Vishva M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4094295/
https://ncbi.nlm.nih.gov/pubmed/23371553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1232253
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