Tuning Pharmacokinetics and Biodistribution of a Targeted Drug Delivery System Through Incorporation of a Passive Targeting Component

Major challenges in the development of drug delivery systems (DDSs) have been the short half-life, poor bioavailability, insufficient accumulation and penetration of the DDSs into the tumor tissue. Understanding the pharmacokinetic (PK) parameters of the DDS is essential to overcome these challenges...

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Hauptverfasser: Kudgus, Rachel A., Walden, Chad A., McGovern, Renee M., Reid, Joel M., Robertson, J. David, Mukherjee, Priyabrata
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4092331/
https://ncbi.nlm.nih.gov/pubmed/25011609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep05669
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