Non-Circadian Expression Masking Clock-Driven Weak Transcription Rhythms in U2OS Cells

U2OS cells harbor a circadian clock but express only a few rhythmic genes in constant conditions. We identified 3040 binding sites of the circadian regulators BMAL1, CLOCK and CRY1 in the U2OS genome. Most binding sites even in promoters do not correlate with detectable rhythmic transcript levels. L...

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Detaylı Bibliyografya
Asıl Yazarlar: Hoffmann, Julia, Symul, Laura, Shostak, Anton, Fischer, Tamás, Naef, Felix, Brunner, Michael
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2014
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4090172/
https://ncbi.nlm.nih.gov/pubmed/25007071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0102238
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