Soluble CD27-pool in humans may contribute to T-cell activation and tumor immunity

The interaction between CD27 and its ligand CD70 has been implicated in regulating cellular immune responses to cancer. Here we report on the role of soluble CD27 (sCD27) in T-cell activation and its elevation in the serum of cancer patients after immunotherapy. In vitro, sCD27 is preferentially der...

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Bibliografiske detaljer
Main Authors: Huang, Jianping, Jochems, Caroline, Anderson, Austin M., Talaie, Tara, Jales, Alessandra, Madan, Ravi A., Hodge, James W., Tsang, Kwong Y., Liewehr, David J., Steinberg, Seth M., Gulley, James L., Schlom, Jeffrey
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4084782/
https://ncbi.nlm.nih.gov/pubmed/23677477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1300022
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