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SOX2 hypomorphism disrupts development of the prechordal floor and optic cup

Haploinsufficiency for the HMG-box transcription factor SOX2 results in abnormalities of the human ventral forebrain and its derivative structures. These defects include anophthalmia (absence of eye), microphthalmia (small eye) and hypothalamic hamartoma (HH), an overgrowth of the ventral hypothalam...

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Bibliografiske detaljer
Main Authors: Langer, Lee, Taranova, Olena, Sulik, Kathleen, Pevny, Larysa
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4077342/
https://ncbi.nlm.nih.gov/pubmed/22522080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mod.2012.04.001
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