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The extent of error-prone replication restart by homologous recombination is controlled by Exo1 and checkpoint proteins
Genetic instability, a hallmark of cancer, can occur when the replication machinery encounters a barrier. The intra-S-phase checkpoint maintains stalled replication forks in a replication-competent configuration by phosphorylating replisome components and DNA repair proteins to prevent forks from ca...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The Company of Biologists
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4075360/ https://ncbi.nlm.nih.gov/pubmed/24806966 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.152678 |
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