Interleukin 1 Receptor 1 and Interleukin 1β Regulate Megakaryocyte Maturation, Platelet Activation, and Transcript Profile During Inflammation in Mice and Humans

OBJECTIVE: Interleukin 1 Receptor 1 (IL1R1) and its ligand, IL1β, are upregulated in cardiovascular disease, obesity, and infection. Previously, we reported a higher level of IL1R1 transcripts in platelets from obese individuals of the Framingham Heart Study (FHS), but its functional effect in plate...

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Main Authors: Beaulieu, Lea M., Lin, Elaine, Mick, Eric, Koupenova, Milka, Weinberg, Ellen O., Kramer, Carolyn D., Genco, Caroline A., Tanriverdi, Kahraman, Larson, Martin G., Benjamin, Emelia J., Freedman, Jane E.
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4070375/
https://ncbi.nlm.nih.gov/pubmed/24458711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.113.302700
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