Discovery of Potent, Selective Multidrug And Toxin Extrusion Transporter 1 (MATE1, SLC47A1) Inhibitors Through Prescription Drug Profiling and Computational Modeling

The human multidrug and toxin extrusion (MATE) transporter 1 contributes to the tissue distribution and excretion of many drugs. Inhibition of MATE1 may result in potential drug-drug interactions (DDIs) and alterations in drug exposure and accumulation in various tissues. The primary goals of this p...

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Main Authors: Wittwer, Matthias B., Zur, Arik A., Khuri, Natalia, Kido, Yasuto, Kosaka, Alan, Zhang, Xuexiang, Morrissey, Kari M., Sali, Andrej, Huang, Yong, Giacomini, Kathleen M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2013
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068829/
https://ncbi.nlm.nih.gov/pubmed/23241029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm301302s
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