Conserved Modular Domains Team up to Latch-open Active Protein Kinase Cα

Signaling proteins comprised of modular domains have evolved along with multicellularity as a method to facilitate increasing intracellular bandwidth. The effects of intramolecular interactions between modular domains within the context of native proteins have been largely unexplored. Here we examin...

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Autores principales: Swanson, Carter J., Ritt, Michael, Wang, William, Lang, Michael J., Narayan, Arvind, Tesmer, John J., Westfall, Margaret, Sivaramakrishnan, Sivaraj
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067214/
https://ncbi.nlm.nih.gov/pubmed/24790081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.534750
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