Biochemical Characterization of Quinolinic Acid Phosphoribosyltransferase from Mycobacterium tuberculosis H37Rv and Inhibition of Its Activity by Pyrazinamide

Quinolinic acid phosphoribosyltransferase (QAPRTase, EC 2.4.2.19) is a key enzyme in the de novo pathway of nicotinamide adenine dinucleotide (NAD) biosynthesis and a target for the development of new anti-tuberculosis drugs. QAPRTase catalyzes the synthesis of nicotinic acid mononucleotide from qui...

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Bibliographic Details
Main Authors: Kim, Hyun, Shibayama, Keigo, Rimbara, Emiko, Mori, Shigetarou
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4065032/
https://ncbi.nlm.nih.gov/pubmed/24949952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0100062
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