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PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt
PIKE-A (PIKE-activating Akt), an isoform of PIKE GTPase that enhances phosphatidylinositol 3-kinase (PI3-kinase) activity, specifically binds to active Akt but not PI3-kinase. PIKE-A stimulates Akt activity in a GTP-dependent manner and promotes invasiveness of cancer cell lines. Here, we show that...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC406454/ https://ncbi.nlm.nih.gov/pubmed/15118108 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400921101 |
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