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Emergence, Involution, and Progression to Carcinoma of Mutant Clones in Normal Endometrial Tissues

Sporadic somatic inactivation of genes such as PTEN within histologically normal endometrium (latent precancers) is an early step in endometrial carcinogenesis. We have used clone-specific mutations of PTEN to determine the fate of latent precancers over time in women who do (high risk) and do not (...

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Detalhes bibliográficos
Main Authors: Mutter, George L., Monte, Nicolas M., Neuberg, Donna, Ferenczy, Alex, Eng, Charis
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4058864/
https://ncbi.nlm.nih.gov/pubmed/24662919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-0108
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