Discovery of Potent Dual PPARα Agonists/CB1 Ligands

[Image: see text] This letter describes the synthesis and in vitro and in vivo evaluation of dual ligands targeting the cannabinoid and peroxisome proliferator-activated receptors (PPAR). These compounds were obtained from fusing the pharmacophores of fibrates and the diarylpyrazole rimonabant, a ca...

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Detalhes bibliográficos
Main Authors: Pérez-Fernández, Ruth, Fresno, Nieves, Macías-González, Manuel, Elguero, José, Decara, Juan, Girón, Rocío, Rodríguez-Álvarez, Ana, Martín, María Isabel, Rodríguez de Fonseca, Fernando, Goya, Pilar
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2011
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4056814/
https://ncbi.nlm.nih.gov/pubmed/24936232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200091q
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