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microRNAs join the p53 network — another piece in the tumour-suppression puzzle
Several recent studies have found a conserved microRNA (miRNA) family, the miR-34s, to be direct transcriptional targets of p53. miR-34 activation can recapitulate elements of p53 activity, including induction of cell-cycle arrest and promotion of apoptosis, and loss of miR-34 can impair p53-mediate...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2007
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4053212/ https://ncbi.nlm.nih.gov/pubmed/17914404 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrc2232 |
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