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Partial inhibition of Cdk1 in G(2) phase overrides the SAC and decouples mitotic events

Entry and progression through mitosis has traditionally been linked directly to the activity of cyclin-dependent kinase 1 (Cdk1). In this study we utilized low doses of the Cdk1-specific inhibitor, RO3306 from early G(2) phase onwards. Addition of low doses of RO3306 in G(2) phase induced minor chro...

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主要な著者: McCloy, Rachael A, Rogers, Samuel, Caldon, C Elizabeth, Lorca, Thierry, Castro, Anna, Burgess, Andrew
フォーマット: Artigo
言語:Inglês
出版事項: Landes Bioscience 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4050138/
https://ncbi.nlm.nih.gov/pubmed/24626186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.28401
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