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Major Facilitator Superfamily (MFS) Porters, LacY, FucP and XylE of Escherichia coli Appear to have Evolved Positionally Dissimilar Catalytic Residues without Rearrangement of 3-TMS Repeat Units

Based on alleged functional residue correspondences between FucP and LacY, a recent study has resulted in a proposed model of 3-TMS unit rearrangements [Madej et al., 2013]. We rebut this theory, using seven different lines of evidence. Our observations suggest that these two transporters are homolo...

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Autors principals: Västermark, Åke, Lunt, Bryan, Saier, Milton
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4048653/
https://ncbi.nlm.nih.gov/pubmed/24603210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000358429
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