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Motor neuron death in ALS – programmed by astrocytes?
Motor neurons in ALS die via cell-autonomous and non-cell autonomous mechanisms. Using adult human astrocytes and motor neurons, Re et al (2014) discover that familial and sporadic ALS derived human adult astrocytes secrete neurotoxic factors that selectively kill motor neurons through necroptosis,...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4040524/ https://ncbi.nlm.nih.gov/pubmed/24607221 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2014.02.024 |
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