Diverse mutational pathways converge on saturable chloroquine transport via the malaria parasite’s chloroquine resistance transporter

Mutations in the chloroquine resistance transporter (PfCRT) are the primary determinant of chloroquine (CQ) resistance in the malaria parasite Plasmodium falciparum. A number of distinct PfCRT haplotypes, containing between 4 and 10 mutations, have given rise to CQ resistance in different parts of t...

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Detalhes bibliográficos
Main Authors: Summers, Robert L., Dave, Anurag, Dolstra, Tegan J., Bellanca, Sebastiano, Marchetti, Rosa V., Nash, Megan N., Richards, Sashika N., Goh, Valerie, Schenk, Robyn L., Stein, Wilfred D., Kirk, Kiaran, Sanchez, Cecilia P., Lanzer, Michael, Martin, Rowena E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4035986/
https://ncbi.nlm.nih.gov/pubmed/24728833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1322965111
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