Use of Metformin Alone Is Not Associated with Survival Outcomes of Colorectal Cancer Cell but AMPK Activator AICAR Sensitizes Anticancer Effect of 5-Fluorouracil through AMPK Activation

Colorectal cancer (CRC) is still the third most common cancer and the second most common causes of cancer-related death around the world. Metformin, a biguanide, which is widely used for treating diabetes mellitus, has recently been shown to have a suppressive effect on CRC risk and mortality, but n...

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Detalhes bibliográficos
Main Authors: Sui, Xinbing, Xu, Yinghua, Yang, Jie, Fang, Yong, Lou, Haizhou, Han, Weidong, Zhang, Maolin, Chen, Wei, Wang, Kaifeng, Li, Da, Jin, Wei, Lou, Fang, Zheng, Yu, Hu, Hong, Gong, Liu, Zhou, Xiaoyun, Pan, Qin, Pan, Hongming, Wang, Xian, He, Chao
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4029793/
https://ncbi.nlm.nih.gov/pubmed/24849329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0097781
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