Late-Stage C–H Coupling Enables Rapid Identification of HDAC Inhibitors: Synthesis and Evaluation of NCH-31 Analogues

[Image: see text] We previously reported the discovery of NCH-31, a potent histone deacetylase (HDAC) inhibitor. By utilizing our C–H coupling reaction, we rapidly synthesized 16 analogues (IYS-1 through IYS-15 and IYS-Me) of NCH-31 with different aryl groups at the C4-position of 2-aminothiazole co...

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Bibliografiske detaljer
Main Authors: Sekizawa, Hiromi, Amaike, Kazuma, Itoh, Yukihiro, Suzuki, Takayoshi, Itami, Kenichiro, Yamaguchi, Junichiro
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2014
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027735/
https://ncbi.nlm.nih.gov/pubmed/24900884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500024s
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