Rapid Conversion of Pseudomonas aeruginosa to a Spherical Cell Morphotype Facilitates Tolerance to Carbapenems and Penicillins but Increases Susceptibility to Antimicrobial Peptides

The Gram-negative human pathogen Pseudomonas aeruginosa tolerates high concentrations of β-lactam antibiotics. Despite inhibiting the growth of the organism, these cell wall-targeting drugs exhibit remarkably little bactericidal activity. However, the mechanisms underlying β-lactam tolerance are cur...

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Bibliographic Details
Main Authors: Monahan, Leigh G., Turnbull, Lynne, Osvath, Sarah R., Birch, Debra, Charles, Ian G., Whitchurch, Cynthia B.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Susceptibility
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023726/
https://ncbi.nlm.nih.gov/pubmed/24419348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01901-13
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