Phosphodiesterase 10A Regulates Alcohol and Saccharin Self-Administration in Rats

A history of stress produces increases in rodent relapse-like alcohol self-administration behavior and regional brain gene expression of phosphodiesterase 10A (PDE10A), a dual-specificity cyclic adenosine monophosphate/cyclic guanosine monophosphate-inhibiting enzyme. Here, we tested the hypothesis...

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Autores principales: Logrip, Marian L, Vendruscolo, Leandro F, Schlosburg, Joel E, Koob, George F, Zorrilla, Eric P
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2014
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023146/
https://ncbi.nlm.nih.gov/pubmed/24549104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2014.20
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