H2rs: Deducing evolutionary and functionally important residue positions by means of an entropy and similarity based analysis of multiple sequence alignments

BACKGROUND: The identification of functionally important residue positions is an important task of computational biology. Methods of correlation analysis allow for the identification of pairs of residue positions, whose occupancy is mutually dependent due to constraints imposed by protein structure...

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Main Authors: Janda, Jan-Oliver, Popal, Ajmal, Bauer, Jochen, Busch, Markus, Klocke, Michael, Spitzer, Wolfgang, Keller, Jörg, Merkl, Rainer
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Methodology Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4021312/
https://ncbi.nlm.nih.gov/pubmed/24766829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-15-118
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