Persistent Mitochondrial Hyperpolarization, Increased Reactive Oxygen Intermediate Production, and Cytoplasmic Alkalinization Characterize Altered IL-10 Signaling in Patients with Systemic Lupus Erythematosus

Abnormal death signaling in lymphocytes of systemic lupus erythematosus (SLE) patients has been associated with elevation of the mitochondrial transmembrane potential (Δψ(m)) and increased production of reactive oxygen intermediates (ROI). The resultant ATP depletion sensitizes T cells for necrosis...

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Bibliographic Details
Main Authors: Gergely, Peter, Niland, Brian, Gonchoroff, Nick, Pullmann, Rudolf, Phillips, Paul E., Perl, Andras
Format: Artigo
Language:Inglês
Published: 2002
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4020441/
https://ncbi.nlm.nih.gov/pubmed/12097418
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