Inhibition of Dengue Virus Replication by a Class of Small-Molecule Compounds That Antagonize Dopamine Receptor D4 and Downstream Mitogen-Activated Protein Kinase Signaling

Dengue viruses (DENV) are endemic pathogens of tropical and subtropical regions that cause significant morbidity and mortality worldwide. To date, no vaccines or antiviral therapeutics have been approved for combating DENV-associated disease. In this paper, we describe a class of tricyclic small-mol...

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Main Authors: Smith, Jessica L., Stein, David A., Shum, David, Fischer, Matthew A., Radu, Constantin, Bhinder, Bhavneet, Djaballah, Hakim, Nelson, Jay A., Früh, Klaus, Hirsch, Alec J.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2014
נושאים:
Vaccines and Antiviral Agents
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019099/
https://ncbi.nlm.nih.gov/pubmed/24599995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00365-14
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