Discovery of a Novel Series of CRTH2 (DP2) Receptor Antagonists Devoid of Carboxylic Acids

[Image: see text] Antagonism of the CRTH2 receptor represents a very attractive target for a variety of allergic diseases. Most CRTH2 antagonists known to date possess a carboxylic acid moiety, which is essential for binding. However, potential acid metabolites O-acyl glucuronides might be linked to...

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Auteurs principaux: Crosignani, Stefano, Jorand-Lebrun, Catherine, Campbell, Gordon, Prêtre, Adeline, Grippi-Vallotton, Tania, Quattropani, Anna, Bouscary-Desforges, Gwenaelle, Bombrun, Agnes, Missotten, Marc, Humbert, Yves, Frémaux, Christèle, Pâquet, Mikaël, El Harkani, Kamel, Bradshaw, Charles G., Cleva, Christophe, Abla, Nada, Daff, Hamina, Schott, Olivier, Pittet, Pierre-André, Arrighi, Jean-François, Gaudet, Marilène, Johnson, Zoë
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2011
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018148/
https://ncbi.nlm.nih.gov/pubmed/24900284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200223s
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