Discovery of AMG 853, a CRTH2 and DP Dual Antagonist

[Image: see text] Prostaglandin D(2) (PGD(2)) plays a key role in mediating allergic reactions seen in asthma, allergic rhinitis, and atopic dermatitis. PGD(2) exerts its activity through two G protein-coupled receptors (GPCRs), prostanoid D receptor (DP or DP(1)), and chemoattractant receptor-homol...

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Main Authors: Liu, Jiwen, Li, An-Rong, Wang, Yingcai, Johnson, Mike G., Su, Yongli, Shen, Wang, Wang, Xuemei, Lively, Sarah, Brown, Matthew, Lai, SuJen, Gonzalez Lopez De Turiso, Felix, Xu, Qingge, Van Lengerich, Bettina, Schmitt, Mike, Fu, Zice, Sun, Ying, Lawlis, Shanna, Seitz, Lisa, Danao, Jay, Wait, Jill, Ye, Qiuping, Tang, Hua Lucy, Grillo, Mark, Collins, Tassie L., Sullivan, Timothy J., Medina, Julio C.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2011
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018074/
https://ncbi.nlm.nih.gov/pubmed/24900313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml1002234
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