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In Vitro Lipolysis Data Does Not Adequately Predict the In Vivo Performance of Lipid-Based Drug Delivery Systems Containing Fenofibrate

The present study investigated the utility of in vitro lipolysis performance indicators drug solubilization and maximum supersaturation ratio (SR(M)) for their predictive use for the in vivo performance in a minipig model. The commercial Lipanthyl formulation and a series of LbDDS based on identical...

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Bibliografische gegevens
Hoofdauteurs: Thomas, Nicky, Richter, Katharina, Pedersen, Thomas B., Holm, René, Müllertz, Anette, Rades, Thomas
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Springer US 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4012058/
https://ncbi.nlm.nih.gov/pubmed/24687210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-014-9589-4
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