In Vitro Lipolysis Data Does Not Adequately Predict the In Vivo Performance of Lipid-Based Drug Delivery Systems Containing Fenofibrate

The present study investigated the utility of in vitro lipolysis performance indicators drug solubilization and maximum supersaturation ratio (SR(M)) for their predictive use for the in vivo performance in a minipig model. The commercial Lipanthyl formulation and a series of LbDDS based on identical...

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Bibliographic Details
Main Authors: Thomas, Nicky, Richter, Katharina, Pedersen, Thomas B., Holm, René, Müllertz, Anette, Rades, Thomas
Format: Artigo
Language:Inglês
Published: Springer US 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4012058/
https://ncbi.nlm.nih.gov/pubmed/24687210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-014-9589-4
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