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In Vitro Lipolysis Data Does Not Adequately Predict the In Vivo Performance of Lipid-Based Drug Delivery Systems Containing Fenofibrate

The present study investigated the utility of in vitro lipolysis performance indicators drug solubilization and maximum supersaturation ratio (SR(M)) for their predictive use for the in vivo performance in a minipig model. The commercial Lipanthyl formulation and a series of LbDDS based on identical...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Thomas, Nicky, Richter, Katharina, Pedersen, Thomas B., Holm, René, Müllertz, Anette, Rades, Thomas
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Springer US 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4012058/
https://ncbi.nlm.nih.gov/pubmed/24687210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-014-9589-4
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