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Improved chemical synthesis of hydrophobic Aβ peptides using addition of C-terminal lysines later removed by carboxypeptidase B

Many amyloidogenic peptides are highly hydrophobic, introducing significant challenges to obtaining high quality peptides by chemical synthesis. For example, while good yield and purity can be obtained in the solid phase synthesis of the Alzheimer’s plaque peptide Aβ(40), addition of a C-terminal Il...

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Bibliografske podrobnosti
Main Authors: Chemuru, Saketh, Kodali, Ravindra, Wetzel, Ronald
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010528/
https://ncbi.nlm.nih.gov/pubmed/24488729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bip.22470
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