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Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate’s protective effect in EAE
Taken orally, the drug dimethyl fumarate (DMF) has been shown to improve functional outcomes for patients with MS; however, it is unclear how DMF mediates a protective effect. DMF and, more so, its active metabolite, monomethyl fumarate, are known agonists of the hydroxycarboxylic acid receptor 2 (H...
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| Główni autorzy: | , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Society for Clinical Investigation
2014
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4001545/ https://ncbi.nlm.nih.gov/pubmed/24691444 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI72151 |
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