Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1

The mitochondrial chaperone mortalin was implicated in Parkinson's disease (PD) because of its reduced levels in the brains of PD patients and disease-associated rare genetic variants that failed to rescue impaired mitochondrial integrity in cellular knockdown models. To uncover the molecular m...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Burbulla, L F, Fitzgerald, J C, Stegen, K, Westermeier, J, Thost, A-K, Kato, H, Mokranjac, D, Sauerwald, J, Martins, L M, Woitalla, D, Rapaport, D, Riess, O, Proikas-Cezanne, T, Rasse, T M, Krüger, R
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2014
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4001296/
https://ncbi.nlm.nih.gov/pubmed/24743735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.103
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