Reconstructing a B-Cell Clonal Lineage. II. Mutation, Selection, and Affinity Maturation

Affinity maturation of the antibody response is a fundamental process in adaptive immunity during which B-cells activated by infection or vaccination undergo rapid proliferation accompanied by the acquisition of point mutations in their rearranged immunoglobulin (Ig) genes and selection for increase...

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Main Authors: Kepler, Thomas B., Munshaw, Supriya, Wiehe, Kevin, Zhang, Ruijun, Yu, Jae-Sung, Woods, Christopher W., Denny, Thomas N., Tomaras, Georgia D., Alam, S. Munir, Moody, M. Anthony, Kelsoe, Garnett, Liao, Hua-Xin, Haynes, Barton F.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2014
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4001017/
https://ncbi.nlm.nih.gov/pubmed/24795717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2014.00170
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