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Morphine Induces Redox-Based Changes in Global DNA Methylation and Retrotransposon Transcription by Inhibition of Excitatory Amino Acid Transporter Type 3–Mediated Cysteine Uptake

Canonically, opioids influence cells by binding to a G protein–coupled opioid receptor, initiating intracellular signaling cascades, such as protein kinase, phosphatidylinositol 3-kinase, and extracellular receptor kinase pathways. This results in several downstream effects, including decreased leve...

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Hlavní autoři: Trivedi, Malav, Shah, Jayni, Hodgson, Nathaniel, Byun, Hyang-Min, Deth, Richard
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3990020/
https://ncbi.nlm.nih.gov/pubmed/24569088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.091728
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