Structural Basis of Improved Second-Generation 3-Nitro-tyrosine tRNA Synthetases

[Image: see text] Genetic code expansion has provided the ability to site-specifically incorporate a multitude of noncanonical amino acids (ncAAs) into proteins for a wide variety of applications, but low ncAA incorporation efficiency can hamper the utility of this powerful technology. When investig...

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Main Authors: Cooley, Richard B., Feldman, Jessica L., Driggers, Camden M., Bundy, Taylor A., Stokes, Audrey L., Karplus, P. Andrew, Mehl, Ryan A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Chemical Society 2014
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3985459/
https://ncbi.nlm.nih.gov/pubmed/24611875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi5001239
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