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Tdrkh is essential for spermatogenesis and participates in primary piRNA biogenesis in the germline

Piwi proteins and Piwi-interacting RNAs (piRNAs) repress transposition, regulate translation, and guide epigenetic programming in the germline. Here, we show that an evolutionarily conserved Tudor and KH domain-containing protein, Tdrkh (a.k.a. Tdrd2), is required for spermatogenesis and involved in...

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Bibliografske podrobnosti
Main Authors: Saxe, Jonathan P, Chen, Mengjie, Zhao, Hongyu, Lin, Haifan
Format: Artigo
Jezik:Inglês
Izdano: European Molecular Biology Organization 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3981179/
https://ncbi.nlm.nih.gov/pubmed/23714778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.121
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