Histone deacetylase 6 inhibition improves memory and reduces total tau levels in a mouse model of tau deposition

INTRODUCTION: Tau pathology is associated with a number of age-related neurodegenerative disorders. Few treatments have been demonstrated to diminish the impact of tau pathology in mouse models and none are yet effective in humans. Histone deacetylase 6 (HDAC6) is an enzyme that removes acetyl group...

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Main Authors: Selenica, Maj-Linda, Benner, Leif, Housley, Steven B, Manchec, Barbara, Lee, Daniel C, Nash, Kevin R, Kalin, Jay, Bergman, Joel A, Kozikowski, Alan, Gordon, Marcia N, Morgan, Dave
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978441/
https://ncbi.nlm.nih.gov/pubmed/24576665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/alzrt241
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